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B淋巴細(xì)胞白血病/淋巴瘤11/鋅指蛋白856抗體
  • 產(chǎn)品貨號(hào):
    BN40311R
  • 中文名稱:
    B淋巴細(xì)胞白血病/淋巴瘤11/鋅指蛋白856抗體
  • 英文名稱:
    Rabbit anti-Ctip1 Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號(hào)

    產(chǎn)品規(guī)格

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  • BN40311R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Mouse,Rat(predicted:Human,Chicken,Rabbit) 推薦應(yīng)用:WB,IHC-P,ELISA

  • BN40311R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Mouse,Rat(predicted:Human,Chicken,Rabbit) 推薦應(yīng)用:WB,IHC-P,ELISA

產(chǎn)品描述

英文名稱Ctip1
中文名稱B淋巴細(xì)胞白血病/淋巴瘤11/鋅指蛋白856抗體
別    名BCL-11A; B cell CLL/lymphoma 11A (zinc finger protein); B cell CLL/lymphoma 11A (zinc finger protein) isoform 2; B cell CLL/lymphoma 11A; B cell lymphoma/leukaemia 11A; B-cell CLL/lymphoma 11A; B-cell lymphoma/leukemia 11A; BC11A_HUMAN; BCL 11A; BCL-11A; BCL11A; BCL11A B cell CLL/lymphoma 11A (zinc finger protein) isoform 1; BCL11A L; BCL11A S; BCL11A XL; BCL11AL; BCL11AS; BCL11AXL; C2H2 type zinc finger protein; COUP TF interacting protein 1; COUP-TF-interacting protein 1; Ctip 1; CTIP1; Ecotropic viral integration site 9; Ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; Evi 9; EVI-9; Evi9; FLJ10173; FLJ34997; HBFQTL5; KIAA1809; Zinc finger protein 856; ZNF856.  
研究領(lǐng)域腫瘤  轉(zhuǎn)錄調(diào)節(jié)因子  淋巴細(xì)胞  b-淋巴細(xì)胞  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Rabbit, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量91kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Ctip1:751-835/835 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1.

Subunit:
Interacts with TFCOUP1, PIAS3, ARP1 and EAR2

Subcellular Location:
Cytoplasm. Nucleus. Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.

Tissue Specificity:
Expressed at high levels in brain, spleen thymus, bone marrow and testis. Expressed in CD34-positive myeloid precursor cells, B-cells, monocytes and megakaryocytes. Expression is tightly regulated during B-cell development.

Post-translational modifications:
Sumoylated by SUMO1.

DISEASE:
Note=Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification.

Similarity:
Contains 6 C2H2-type zinc fingers.

SWISS:
Q9H165

Gene ID:
53335

Database links:

Entrez Gene: 53335 Human

Entrez Gene: 14025 Mouse

Omim: 606557 Human

SwissProt: Q9H165 Human

SwissProt: Q9QYE3 Mouse

Unigene: 370549 Human

Unigene: 441102 Mouse

Unigene: 471050 Mouse

Unigene: 53687 Mouse

Unigene: 88824 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.