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精神分裂癥與犰狳重復基因抗體
  • 產(chǎn)品貨號：
    BN40372R
  • 中文名稱：
    精神分裂癥與犰狳重復基因抗體
  • 英文名稱：
    Rabbit anti-ARVCF Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN40372R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40372R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Dog,Pig,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱ARVCF
中文名稱精神分裂癥與犰狳重復基因抗體
別    名Armadillo repeat gene deletes in velocardiofacial syndrome; Armadillo repeat protein; Armadillo repeat protein deleted in velo cardio facial syndrome; Armadillo repeat protein deleted in velo-cardio-facial syndrome; ARVC_HUMAN; Arvcf; FLJ35345; OTTHUMP00000028704; OTTHUMP00000198346; OTTHUMP00000198347; OTTHUMP00000198348.  
研究領域細胞生物  信號轉導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Dog, Pig, Horse, Rabbit, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量105kDa
細胞定位細胞核 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ARVCF:501-600/962 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010].

Function:
Involved in protein-protein interactions at adherens junctions.

Subunit:
Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain).

Tissue Specificity:
Found in all the examined tissues including heart, brain, liver and kidney. Found at low level in lung.

Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.

SWISS:
O00192

Gene ID:
421

Database links:

Entrez Gene: 421 Human

Omim: 602269 Human

SwissProt: O00192 Human

Unigene: 699354 Human

Unigene: 713616 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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