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Fcγ免疫球蛋白IgG結合蛋白抗體

產品貨號：

BN40411R
中文名稱：

Fcγ免疫球蛋白IgG結合蛋白抗體
英文名稱：

Rabbit anti-FCGBP Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN40411R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN40411R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rat(predicted:Dog,Rabbit) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	FCGBP
中文名稱	Fcγ免疫球蛋白IgG結合蛋白抗體
別名	Fc fragment of IgG binding protein; FC(GAMMA)BP; Fcgamma-binding protein antigen; FcgammaBP; FCGBP; FCGBP_HUMAN; Human Fc gamma BP; IgGFc-binding protein.
研究領域	細胞生物免疫學細胞膜受體
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rat, (predicted: Dog, Rabbit, )
產品應用	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	569kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human FCGBP:431-530/5405
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains. It is predominantly expressed in placenta and colon epithelium as well as in thyroid and serum. Patients with various autoimmune diseases seemingly have higher levels of FCGBP protein present in their serum. Function: May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa. Subunit: Interacts with the Fc portion of IgG and with MUC2. Subcellular Location: Secreted. Tissue Specificity: Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level). Similarity: Contains 12 TIL (trypsin inhibitory-like) domains. Contains 13 VWFD domains. SWISS: Q9Y6R7 Gene ID: 8857 Database links: Entrez Gene: 8857 Human SwissProt: Q9Y6R7 Human Unigene: 111732 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.