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氧化還原酶GlyR1/核蛋白60抗體
  • 產(chǎn)品貨號(hào)：
    BN40422R
  • 中文名稱：
    氧化還原酶GlyR1/核蛋白60抗體
  • 英文名稱：
    Rabbit anti-GLYR1 Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN40422R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

  • BN40422R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Mouse(predicted:Human,Rat,Chicken,Dog,Pig,Cow,Horse,Monkey) 推薦應(yīng)用：WB,IHC-P,IHC-F,ICC,IF,ELISA

產(chǎn)品描述

英文名稱GLYR1
中文名稱氧化還原酶GlyR1/核蛋白60抗體
別    名3 hydroxyisobutyrate dehydrogenase like protein; 3-hydroxyisobutyrate dehydrogenase-like protein; BM045; Cytokine like nuclear factor n pac; Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; GLYR1; GLYR1_HUMAN; HIBDL; N-PAC; NP60; Nuclear protein 60 kDa; Nuclear protein NP60; Nuclear protein of 60 kDa; Putative oxidoreductase GLYR1.  
研究領(lǐng)域細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Monkey, )
產(chǎn)品應(yīng)用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量61kDa
細(xì)胞定位細(xì)胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human GLYR1/NP60:21-120/553 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹NP60 is a 553 amino acid nuclear protein that regulates the phosphorylation and activation of p38 alpha in response to stress. There are five isoforms of NP60 that are produced as a result of alternative splicing events.

Function:
May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).

Subunit:
Interacts with MAPK14.

Subcellular Location:
Nucleus.

Similarity:
Belongs to the 3-hydroxyisobutyrate dehydrogenase family.
NP60 subfamily. Contains 1 A.T hook DNA-binding domain.
Contains 1 PWWP domain.

SWISS:
Q49A26

Gene ID:
84656

Database links:

Entrez Gene: 84656 Human

Entrez Gene: 74022 Mouse

Entrez Gene: 360477 Rat

Omim: 610660 Human

SwissProt: Q49A26 Human

SwissProt: Q922P9 Mouse

SwissProt: Q5RKH0 Rat

Unigene: 387255 Human

Unigene: 21652 Mouse

Unigene: 2639 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.