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首頁>>免疫學>>一抗>>宮頸癌抑制蛋白4抗體
宮頸癌抑制蛋白4抗體
  • 產品貨號：
    BN40428R
  • 中文名稱：
    宮頸癌抑制蛋白4抗體
  • 英文名稱：
    Rabbit anti-ZAK Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規格

    售價

    備注

  • BN40428R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

  • BN40428R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep) 推薦應用：IHC-P,IHC-F,ICC,IF,ELISA

產品描述

英文名稱ZAK
中文名稱宮頸癌抑制蛋白4抗體
別    名AZK; Cervical cancer suppressor gene 4 protein; HCCS 4; HCCS-4; HCCS4; Human cervical cancer suppressor gene 4 protein; Leucine zipper and sterile alpha motif containing kinase; Leucine zipper- and sterile alpha motif-containing kinase; Mitogen activated protein kinase kinase kinase MLT; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase 7; Mixed lineage kinase related kinase; Mixed lineage kinase related kinase MRK beta; Mixed lineage kinase with a leucine zipper and a sterile alpha motif; Mixed lineage kinase-related kinase; MLK 7; MLK like mitogen activated protein triple kinase; MLK related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; MLK7; Mlklak; MLT; MLTK; MLTK_HUMAN; MRK; Sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; ZAK.  
研究領域腫瘤  細胞生物  信號轉導  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:200-800 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量91kDa
細胞定位細胞核 細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human ZAK/HCCS4:1-100/800 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.

Function:
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.

Subunit:
Homodimer. Interacts with PKN1 and ZNF33A.

Subcellular Location:
Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.

Tissue Specificity:
Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
MAP kinase kinase kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 SAM (sterile alpha motif) domain.

SWISS:
Q9NYL2

Gene ID:
51776

Database links:

Entrez Gene: 51776 Human

Entrez Gene: 65964 Mouse

Entrez Gene: 311743 Rat

Omim: 609479 Human

SwissProt: Q9NYL2 Human

SwissProt: Q9ESL4 Mouse

Unigene: 444451 Human

Unigene: 304143 Mouse

Unigene: 314618 Mouse

Unigene: 168007 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.