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載脂蛋白1抗體
  • 產品貨號:
    BN41944R
  • 中文名稱:
    載脂蛋白1抗體
  • 英文名稱:
    Rabbit anti-CD95/FAS Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號

    產品規格

    售價

    備注

  • BN41944R-50ul

    50ul

    ¥1486.00

    交叉反應:Human,Mouse,Rat(predicted:Pig) 推薦應用:WB,Flow-Cyt,ELISA

  • BN41944R-100ul

    100ul

    ¥2360.00

    交叉反應:Human,Mouse,Rat(predicted:Pig) 推薦應用:WB,Flow-Cyt,ELISA

  • BN41944R-200ul

    200ul

    ¥3490.00

    交叉反應:Human,Mouse,Rat(predicted:Pig) 推薦應用:WB,Flow-Cyt,ELISA

產品描述

英文名稱CD95/FAS
中文名稱載脂蛋白1抗體
別    名Apo-1; ALPS 1A; ALPS1A; APO 1; Apo 1 antigen; APO 1 cell surface antigen; Apo-1 antigen; APO1; Apo1 antigen; APO1 cell surface antigen; Apoptosis antigen 1; Apoptosis mediating surface antigen FAS; Apoptosis-mediating surface antigen FAS; APT 1; APT1; CD 95; CD 95 antigen; CD95; CD95 antigen; Delta Fas; Delta Fas/APO 1/CD95; Delta Fas/APO1/CD95; FAS 1; FAS 827dupA; Fas AMA; FAS; FAS Antigen; FAS1; FASLG receptor; FASTM; TNF receptor superfamily, member 6; TNFRSF 6; TNFRSF6; TNR6_HUMAN; Tumor necrosis factor receptor superfamily member 6.  




研究領域細胞生物  免疫學  細胞凋亡  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse, Rat,  (predicted: Pig, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 Flow-Cyt=1μg/Test 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
細胞定位細胞膜 分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human FAS/Apo-1/CD95:81-170/335 <Extracellular>
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Function:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).

Subunit:
Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD.

Subcellular Location:
Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2, 3, 4, 5, 6: Secreted.

Tissue Specificity:
Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.

Post-translational modifications:
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.

DISEASE:
Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.

Similarity:
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

SWISS:
P25445

Gene ID:
355

Database links:

Entrez Gene: 355 Human

Entrez Gene: 14102 Mouse

Entrez Gene: 246097 Rat

Omim: 134637 Human

SwissProt: P25445 Human

SwissProt: P25446 Mouse

SwissProt: Q63199 Rat

Unigene: 244139 Human

Unigene: 1626 Mouse

Unigene: 162521 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications



















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