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首頁>>免疫學>>一抗>>內質網核信號轉導蛋白a1抗體
內質網核信號轉導蛋白a1抗體
  • 產品貨號：
    BN41967R
  • 中文名稱：
    內質網核信號轉導蛋白a1抗體
  • 英文名稱：
    Rabbit anti-IRE1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規格

    售價

    備注

  • BN41967R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41967R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

  • BN41967R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse,Dog,Pig,Cow,Horse,Rabbit) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt,ELISA

產品描述

英文名稱IRE1
中文名稱內質網核信號轉導蛋白a1抗體
別    名IRE1a; Endoplasmic reticulum (ER) to nucleus signalling 1; Endoplasmic reticulum to nucleus signaling 1; Endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signaling 1; ERN 1; ERN1; ERN1_HUMAN; hIRE 1p; hIRE1p; Inositol requiring 1; Inositol requiring protein 1; Inositol-requiring protein 1; IRE-1; IRE 1; IRE 1a; IRE 1P; Ire1 alpha; Ire1-alpha; Ire1alpha; IRE1P; MGC163277; Protein kinase/endoribonuclease; Serine/threonine protein kinase/endoribonuclease IRE1.  



研究領域細胞生物  信號轉導  激酶和磷酸酶  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, )
產品應用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量105kDa
細胞定位細胞漿 細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human IRE1a:252-260/977 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq, Jul 2008]

Function:
Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

Subunit:
Homodimer; disulfide-linked. Dimer formation is driven by hydrophobic interactions within the N-terminal luminal domains and stabilized by disulfide bridges. Also binds HSPA5, a negative regulator of the unfolded protein response. This interaction may disrupt homodimerization and prevent activation of ERN1. Interacts with TAOK3 and TRAF2.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Ubiquitously expressed. High levels observed in pancreatic tissue.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Contains 1 KEN domain.
Contains 1 protein kinase domain.

SWISS:
O75460

Gene ID:
2081

Database links:

Entrez Gene: 2081 Human

Entrez Gene: 78943 Mouse

Entrez Gene: 498013 Rat

Omim: 604033 Human

SwissProt: O75460 Human

SwissProt: Q9EQY0 Mouse

Unigene: 133982 Human

Unigene: 592041 Human

Unigene: 700027 Human

Unigene: 20452 Mouse

Unigene: 340943 Mouse

Unigene: 226435 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

















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