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KLF4重組兔單克隆抗體
  • 產(chǎn)品貨號：
    BN42148R
  • 中文名稱：
    KLF4重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-KLF4 Monoclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

    備注

  • BN42148R-50ul

    50ul

    ￥2020.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

  • BN42148R-100ul

    100ul

    ￥3240.00

    交叉反應：Human,Mouse(predicted:Rat) 推薦應用：WB,IHC-P,IHC-F,ICC,IF,Flow-Cyt

產(chǎn)品描述

英文名稱KLF4
中文名稱KLF4重組兔單克隆抗體
別    名Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4 (Epithelial zinc finger protein EZF) (Gut enriched Krueppel like factor); Kruppel like factor 4 (gut); Krueppel-like factor 4;EZF;GKLF;KLF 4;KLF-4;Krueppel like factor 4; KLF4_HUMAN.  
研究領域腫瘤  細胞生物  信號轉(zhuǎn)導  干細胞  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號6C5
交叉反應Human, Mouse,  (predicted: Rat, )
產(chǎn)品應用WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量56kDa
細胞定位細胞核 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant protein within human KLF4 aa 1-500: 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor.

Function:
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

Subunit:
Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain).

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.

SWISS:
O43474

Gene ID:
9314

Database links:

Entrez Gene: 9314 Human

Entrez Gene: 16600 Mouse

Omim: 602253 Human

SwissProt: O43474 Human

SwissProt: Q60793 Mouse

Unigene: 376206 Human

Unigene: 4325 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.