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泛素蛋白連接酶重組兔單克隆抗體
  • 產(chǎn)品貨號(hào)：
    BN42167R
  • 中文名稱：
    泛素蛋白連接酶重組兔單克隆抗體
  • 英文名稱：
    Rabbit anti-Fbx32 Monoclonal antibody
  • 品牌：
    Biorigin

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  • BN42167R-50ul

    50ul

    ￥2020.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human) 推薦應(yīng)用：WB,ICC

  • BN42167R-100ul

    100ul

    ￥3240.00

    交叉反應(yīng)：Mouse,Rat(predicted:Human) 推薦應(yīng)用：WB,ICC

產(chǎn)品描述

英文名稱Fbx32
中文名稱泛素蛋白連接酶重組兔單克隆抗體
別    名Fbx32; 4833442G10Rik; AI430017; Atrogin 1; Atrogin-1; ATROGIN1; Atrophy gene 1; F box only protein 32; F-box only protein 32; F-box protein 32; FBX32_HUMAN; fbxo25; FBXO32; FLJ32424; MAFbx; MGC108443; MGC137646; MGC33610; Muscle atrophy F box; Muscle atrophy F box protein; Muscle atrophy F-box protein.  
研究領(lǐng)域細(xì)胞生物  干細(xì)胞  泛素  
抗體來源Rabbit
克隆類型Monoclonal
克 隆 號(hào)2A3
交叉反應(yīng)Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用WB=1:500-1000 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量42kDa
細(xì)胞定位細(xì)胞核 細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原Recombinant human Fbx32:1-200/355 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹Fbx32 is an E3 ubiquitin ligase that initiates ATP dependent ubiquitin-mediated proteolysis and promotes muscle atrophy. It is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. It is also thought to recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation during skeletal muscle atrophy. Fbx32 interacts with MyoD by ubiquitination via a sequence found in transcriptional coactivators and therefore may play an important role in the course of muscle differentiation by determining the abundance of MyoD.

Function:
Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.

Subunit:
Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between Cytoplasm and the nucleus.

Tissue Specificity:
Specifically expressed in cardiac and skeletal muscle.

Similarity:
Contains 1 F-box domain.

SWISS:
Q969P5

Gene ID:
114907

Database links:

Entrez Gene: 513776 Cow

Entrez Gene: 114907 Human

Entrez Gene: 67731 Mouse

Entrez Gene: Q2KHT6 Pig

Entrez Gene: 171043 Rat

Omim: 606604 Human

SwissProt: Q2KHT6 Cow

SwissProt: Q969P5 Human

SwissProt: Q9CPU7 Mouse

SwissProt: Q1A730 Pig

SwissProt: Q91Z62 Rat

Unigene: 403933 Human

Unigene: 292042 Mouse

Unigene: 72619 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.