高h肉辣文交换_好吊妞视频haodiaoniucom_羞羞漫画登录页面免费入口_美国一级片视频

最近搜索：細胞培養微生物學分子生物生物化學

首頁>>免疫學>>一抗>>金屬蛋白酶組織抑制因子-1抗體

金屬蛋白酶組織抑制因子-1抗體

產品貨號：

BN42175R
中文名稱：

金屬蛋白酶組織抑制因子-1抗體
英文名稱：

Rabbit anti-TIMP-1 Polyclonal antibody
品牌：

Biorigin

貨號

產品規格

售價

備注
BN42175R-50ul

50ul

￥1486.00

交叉反應：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN42175R-100ul

100ul

￥2360.00

交叉反應：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA
BN42175R-200ul

200ul

￥3490.00

交叉反應：Human,Mouse,Rabbit(predicted:Rat,Dog,Pig,Cow,Sheep) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱	TIMP-1
中文名稱	金屬蛋白酶組織抑制因子-1抗體
別名	Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.

研究領域	腫瘤細胞生物神經生物學細胞凋亡生長因子和激素激酶和磷酸酶合成與降解
抗體來源	Rabbit
克隆類型	Polyclonal
交叉反應	Human, Mouse, Rabbit, (predicted: Rat, Dog, Pig, Cow, Sheep, )
產品應用	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	21kDa
細胞定位	分泌型蛋白
性狀	Liquid
濃度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TIMP-1:103-207/207
亞型	IgG
純化方法	affinity purified by Protein A
儲存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed	PubMed
產品介紹	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]. Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP1 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P01033 Gene ID: 7076 Database links: Entrez Gene: 7076 Human Entrez Gene: 21857 Mouse Omim: 305370 Human SwissProt: P01033 Human SwissProt: P12032 Mouse Unigene: 522632 Human Unigene: 8245 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成與降解（Synthesis and Degradation） TIMP1是基質金屬蛋白酶的抑制酶，其功能與MMP相反，能抑制腫瘤細胞的浸潤和轉移，主要用于各種惡性腫瘤如乳腺癌等的研究。TIMP-1是一種28kDa的糖蛋白，主要分泌細胞為多種結締組織細胞，被認為是組織中MMPs活性的主要調節者，它可以和MMPs家族成員以共價鍵方式形成1:1的復合物，從而發揮其抑制作用。在正常生理條件下，MMPs和TIMPs之間的平衡狀態是維持細胞外基質正常狀態所必需的，一旦它們之間的比例失調，就會造成一系列的病理狀態。